GLP-1 Medications Like Ozempic: What Works, What Doesn’t, and What Comes After

GLP-1 medications like Ozempic, Wegovy, and Mounjaro have changed the weight loss conversation. For many of my patients, they’ve brought relief, hope, and real results. For others, they’ve brought confusion, side effects, and more questions than answers.

GLP-1 medications like Ozempic, Wegovy, and Mounjaro have changed the weight loss conversation. For many of my patients, they’ve brought relief, hope, and real results. For others, they’ve brought confusion, side effects, and more questions than answers.

I prescribe these medications thoughtfully and I always pair them with context.

If you’re trying to figure out whether GLP-1s are right for you, what to expect, or how to avoid the common pitfalls, this is a good place to start. I’ll walk you through the science, the benefits, the risks, and what I tell my own patients about what comes next.

First, What Are GLP-1 Medications?

GLP-1s (glucagon-like peptide-1 receptor agonists) are a class of medications originally developed for Type 2 diabetes. They work by mimicking a hormone your gut already produces, which helps regulate blood sugar and appetite.

Brand names you may have heard include:

  • Ozempic (semaglutide) – FDA-approved for Type 2 diabetes
  • Wegovy (semaglutide at a higher dose) – FDA-approved for weight loss
  • Mounjaro (tirzepatide) – FDA-approved for Type 2 diabetes
  • Zepbound (tirzepatide at a higher dose) – FDA-approved for weight loss

These drugs help you feel fuller, slower. They reduce cravings, improve insulin sensitivity, and promote steady, sustainable fat loss when used properly.

Do They Work?

Yes, they work. Especially for people struggling with biologically driven weight gain. The results I see in clinic vary, but the benefits are real:

  • Reduced body fat, especially around the abdomen
  • Lowered A1C and fasting glucose
  • Improved blood pressure and cholesterol
  • Decreased food noise and cravings
  • Increased energy and motivation

But they aren’t magic. And they aren’t for everyone. More on that below.

What They Don’t Do

GLP-1s don’t fix everything.

  • They don’t teach you how to eat in a sustainable way.
  • They don’t address emotional or stress-based eating habits.
  • They don’t build muscle or improve fitness on their own.
  • They don’t prevent weight regain once you stop taking them—unless you’ve changed the underlying patterns.
Dr. Tassa’s Note: In other words, these medications are a powerful tool. But they’re not a lifestyle.

What About Side Effects?

Side effects are common, especially in the first 4–6 weeks. Most are manageable, but it’s important to work with someone who can guide you.

Common side effects include:

  • Nausea or upset stomach
  • Constipation or diarrhea
  • Fatigue or dizziness
  • Decreased appetite to the point of skipping meals
  • Muscle loss if protein intake and exercise aren't dialed in

Dr. Tassa’s Note: Some patients feel amazing. Others need to switch formulations or pause treatment. I always start low and adjust gradually, based on your labs, feedback, and goals.

Who Is a Good Candidate?

I look at three key areas:

  1. BMI and body composition – GLP-1s are typically prescribed for those with a BMI over 27 with related conditions, or over 30 without. But BMI isn’t the full story.
  2. Metabolic markers – Elevated A1C, insulin resistance, or other metabolic risk factors strengthen the case for treatment.
  3. Lifestyle readiness – You should be open to changing how you eat, move, and think about your body. GLP-1s aren’t a shortcut. They’re a catalyst.

Dr. Tassa’s Note: I always make sure patients are informed and motivated from the right place - not pressured or misled by social media trends.

Why I Use Compounded GLP-1s

Access and cost are two of the biggest barriers to this care. I work with reputable compounding pharmacies that offer safe, effective versions of these medications at a fraction of the cost.

If you’ve been quoted $1,000+ per month for branded injections, I can often cut that down significantly without compromising safety or results.

What Comes After?

This is the part most clinics skip.

Stopping GLP-1s abruptly, without a plan, often leads to weight regain. That’s because:

  • Appetite can rebound
  • Muscle mass may have declined during treatment
  • Old habits creep back in without support

Here’s how we avoid that:

  • We build strength and optimize nutrition during treatment
  • We track markers beyond weight (energy, sleep, bloodwork)
  • We taper doses gradually, not all at once
  • We shift focus toward sustainability as you progress

Dr. Tassa’s Note: Weight maintenance is a skill. I teach it like one.

How I Approach GLP-1 Treatment at Bespoke Medicine

  • You get a full evaluation of labs, history, and lifestyle
  • We talk honestly about your goals and expectations
  • You start at a low dose, with tight follow-up
  • We adjust monthly and build habits alongside the medication
  • You always know what’s next

Dr. Tassa’s Note: No judgment. No shortcuts. No side-effect roulette.

Final Thoughts

There’s nothing wrong with wanting to feel better in your body. GLP-1s can be part of that. But they should never be the whole plan.

If you’re curious about whether this approach is right for you, I’m happy to walk you through it, honestly and clearly.

You don’t need to figure it out alone!

Recent Posts

Stay informed about the latest research in psychology.

Blog Img
Wellness
Is This Perimenopause? 10 Early Signs to Know

If you're between 35 and 50 and something just feels “off” but your labs are normal and your doctor tells you “everything looks fine.” You might be in perimenopause. And no, you’re not imagining it.

Blog Img
Wellness
GLP-1 Medications Like Ozempic: What Works, What Doesn’t, and What Comes After

GLP-1 medications like Ozempic, Wegovy, and Mounjaro have changed the weight loss conversation. For many of my patients, they’ve brought relief, hope, and real results. For others, they’ve brought confusion, side effects, and more questions than answers.

Blog Img
Membership
Why Concierge Care Isn’t Just for the Ultra-Wealthy Anymore

When people hear “concierge medicine,” they usually imagine something out of reach. Private jets, house calls in Malibu, seven-figure salaries, and a doctor on speed dial.It’s a fair stereotype. That’s what concierge care looked like when it first emerged. But things have changed.